The problem of understanding how convolutional neural nets (CNN’s) work and learn is one of the fundamental problems in machine learning. It is important to study both the weights and the activations, as these roughly…
In 2019, the world saw significant advances in the sophistication and pervasive use of artificial intelligence (“AI”). For instance, we witnessed the emergence of next-generation AI-powered natural text generators like…
It remains a significant challenge to define individual protein associations within networks where an individual protein can directly interact with other proteins and/or be part of large complexes, which contain functional…
Aortic stenosis (AS) is the most common valvular lesion, with >1 in 8 individuals aged 75 years and older having moderate or severe AS. The disease starts as focal leaflet thickening with calcification and gradually…
Deep neural networks are a powerful and fascinating methodology for solving problems with large and complex data sets. They use directed graphs as a template for very large computations, and have demonstrated a great…
Sputum induction is a widely applied method of sampling the epithelial lining fluid that lines the lower airways constituting the tracheobronchial tree. It enables assessment of both the cellular and extracellular…
The pathogenesis of ME/CFS, a disease characterized by fatigue, cognitive dysfunction, sleep disturbances, orthostatic intolerance, fever, irritable bowel syndrome (IBS), and lymphadenopathy, is poorly understood. We…
Fragile X syndrome (FXS), due to mutations of the FMR1 gene, is the most common known inherited cause of developmental disability. The cognitive, behavioral, and neurological phenotypes observed in affected individuals…
The microbiome is fundamentally one of the most unique organs in the human body. Dysbiosis can result in critical inflammatory responses and result in pathogenesis contributing to neoplastic events. We used a pan-…
Humans and other mammals are colonized by microbial agents across the kingdom which can represent a unique microbiome pattern. Dysbiosis of the microbiome has been associated with pathology including cancer. We have…