Knowledge Center

Publications
Quantifying similarity of pore-geometry in nanoporous materials

In most applications of nanoporous materials the pore structure is as important as the chemical composition as a determinant of performance. For example, one can alter performance in applications like carbon capture…

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Publications
Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development

Transcriptional programs control cellular lineage commitment and differentiation during development. Understanding of cell fate has been advanced by studying single-cell RNA-sequencing (RNA-seq) but is limited…

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Publications
Syria Polio Vaccination Analyses

SumAll.org used Ayasdi software to perform a quick systemic cluster analysis of a Polio vaccination campaign in Syria for children, with data provided by HumanitarianTracker.org. This humanitarian effort in a…

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Publications
MRI and Biomechanics Multidimensional Data Analysis Reveals R2-R1q as an Early Predictor of Cartilage Lesion Progression in Knee Osteoarthritis

Osteoarthritis (OA) is a complex and multifactorial disorder and a leading cause of chronic disability. OA prevalence in the United States is conservatively estimated at 26.9 million US adults,1 with estimated annual…

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Publications
Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an unexplained, chronic debilitating disorder that in the USA alone is estimated to affect up to 2.5 million people, with annual costs of $24 billion…

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Publications
Machine learning algorithm for automatic detection of CT-identifiable hyperdense lesions associated with traumatic brain injury

Traumatic brain injury (TBI) is a major cause of death and disability in the United States. Time to treatment is often related to patient outcome. Access to cerebral imaging data in a timely manner is a vital component of patient…

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Publications
Spatiotemporal genomic architecture informs precision oncology in glioblastoma

Most clinical trials for targeted therapy in GBM have shown limited clinical success. Although recent genome-wide studies evaluating regional heterogeneity and longitudinal GBM pairs have suggested potential…

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Publications
Identification of Topological Network Modules in Perturbed Protein Interaction Networks

Biological networks consist of functional modules, however detecting and characterizing such modules in networks remains challenging. Perturbing networks is one strategy for identifying modules. Here we used an advanced…

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Publications
TDA applied to reveal pedogenetic principles of European topsoil system

Recent developments in applied mathematics are bringing new tools that are capable to synthesize knowledge in various disciplines, and help in finding hidden relationships between variables. One such technique is…

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